
Kouin and Kyouko are not exactly antagonist but at some point, they clearly are...
Notes:
'Desire' (or Dark Yuuto) (dont vote if u don't know of the original game)
King of Rakios (Im kinda disappointed i couldnt kill him personally)
Kouin of 'Karma' (And Kouin is well, tragic (hero) antagonist ?! Anyway, his way of thinking make me think of him as block head so ...

Kyouko of 'Void' (Kyouko after being devoured by the sword is clearly an antagonist...

Soma Ru Soma (esspecially for Esperia's fans !!!)
Shun Akitsuki (typical extremely regoist whos also a sicko that betrayed his own love to save his pathetic self...I would have forgiven him if he was to became someone like Kouin tho...)
Shun the Ruling sword (typical i-want-to-destroy-the-World boss)
Mitosemar of Defilement (mid-boss) (Dont vote if ur an S&M fan)
Maderio the Moonlight Blades (mid-boss) (For his 100% health dmg skill and his twisted talking style)
Ntushitora the Hellfire (mid-boss) (for being easiest to kill while doesnt look so?)
Takios the Black Blade (typical Lu bu-like warrior)
Temuorin Matriarch (The ulitimate loli, i wonder how old was she when she turned Eternal)
Someone not listed...(I might not have listed everyone so...vote and remind me who)